Other investigations demonstrated that the expression levels of proteins responsible for mitochondrial biogenesis (PGC1a, Tfam, ERRa, NRF1, NRF2, and DNA polymerase subunit gamma) did not significantly change in the spinal cord and peripheral blood mononuclear cells from ALS patients [146]. The gene discussed is PPARGC1A; the disease is amyotrophic lateral sclerosis.