ALS-associated protein FUS has been found to interact with the mitochondrial proteins heat shock proteins 60 (HSP60), also known as chaperonins, β-subunit of ATP synthase, and respiratory chain complex mRNAs; mutations in FUS, which induce FUS redistribution to the cytoplasm, have been associated with mitochondrial fragmentation and network disruption in transfected cells and patient tissues [71,85]. This evidence concerns the gene HSPD1 and amyotrophic lateral sclerosis.