Thus, a number of ALS-associated genes, including the very first identified (SOD1) and recently discovered genes (FUS, TBK1, TARDBP, C9orf72, KIF5A, OPTN, SFPQ, and SQSTM1), have been associated with structural and functional disorders in mitochondria and mislocalized mitochondrial networks. This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.