IL18 and ischemia: It is well-known that after ischemia, activation of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome converts pro-caspase-1 into mature caspase-1, which then activates gasderminD (GSDMD), resulting in pyroptosis of the cells, accompanied by the release of interleukin-18 (IL-18) and interleukin-1β (IL-1β).