Chu et al. explored the immune phenotype characteristics including T cells (CD4+, CD8+, or FOXP3+) and macrophages (CD68+ or CD206+) and found that PC samples with high-risk subtypes of HPV harbored a higher density of stromal Granzyme B+CD8+ T cells compared to HPV− tumors, indicating a highly immunogenic property of HPV [117]. Here, CD4 is linked to pachyonychia congenita.