SP1 and cervical cancer: In addition, they identified several DNA methylation events occurring in five CpGs (position 7535, 7554, 7677, 7683, and 7695) that overlapped with the transcriptional enhancer and six CpGs (position 7862, 31, 37, 43, 52, and 58) that were part of the E2- and SP1-binding sites of the E6 promotor, suggesting similar epigenetic mechanisms associated with HPV16 infection between PC and cervical cancer [29].