LGALS3 and atrial fibrillation: Figure 2 demonstrates the changes during the follow-up period until 6 months after LAAO, showing a peak in galectin-3 around 45 days (control group vs. 45D: p < 0.01; baseline vs. 45D: p = 0.014) and a decrease to levels near baseline at 6 months. Galectin-3 levels did not show a significant difference regarding the type of AF at baseline (paroxysmal AF: 11.7 ± 5.4 ng/mL vs. permanent AF: 12.1 ± 6.3 ng/mL; p = 0.45).