Given our earlier findings that stress-activated p53 can regulate the expression of several members of the A3 gene family [17], we investigated the potential role of p53 in the expression of A3 genes during RSV infection by utilizing a well-defined model system of human lung adenocarcinoma cells that included paired p53+ A549 and p53- H1299 cell lines. This evidence concerns the gene TP53 and lung adenocarcinoma.