Currently, the TRIPLET-HCC phase 2/3 trial (NCT05665348) is planned to assess the efficacy and safety of combining an anti-CTLA-4 with an anti-PD-L1 and an anti-VEGF agent in patients with HCC by comparing treatment with ipilimumab plus atezolizumab and bevacizumab to the atezolizumab plus bevacizumab combination [48]. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.