Finally, a pre-clinical study looking to assess the abscopal effects in the tumors of syngeneic HCC mouse models given RT with or without anti-PD-1 antibodies found significantly an enhanced abscopal effect within the irradiated and non-irradiated tumors in the combination arm, in addition to higher infiltration of activated CD8+ T cells [103]. The gene discussed is CD8A; the disease is hepatocellular carcinoma.