KDR and hepatocellular carcinoma: A phase 3 trial looking to compare camrelizumab plus apatinib (a VEGF-R2 inhibitor) versus sorafenib as first-line therapy for patients with advanced HCC reported significantly improved outcomes in the combination group over sorafenib (median OS: 22.1 vs. 15.2 months; median PFS: 5.6 vs. 3.7 months, respectively; p < 0.0001) [36].