Swine fever virus infection stimulates PARKIN and PINK1 expression and mitochondrial translocation, leading to mitochondrial fission and increased mitophagy [93]; hepatitis B protein recruits PARKIN to destroy depolarized mitochondria by regulating PINK1 expression [94]; and SARS-CoV2 impairs intracellular signaling and affects mitochondrial biogenesis [95]. This evidence concerns the gene PRKN and hepatitis A virus infection.