And during periodontitis, the divergent expression profile driven by the transcriptional regulator Runx2 could be detected in macrophages, indicating the process of osteoblast differentiation led by Runx2 by directly regulating the Wnt, RANKL, FGF, hedgehog and Pthlh signaling molecules; these and other transcription factors under physiology condition were altered [31,32]. This evidence concerns the gene TNFSF11 and periodontitis.