Subsequent activation of AMPK, PGC1α, PPARα, and CD36 promoted the utilization and oxidation of free acids, and increased expression of Glut4 and PDK4 indicated improved glucose utilization, and increased expression of IRS1 also indicated alleviated insulin resistance, which promoted energy production in cardiomyocytes and inhibited heart failure. Here, PDK4 is linked to Insulin resistance.