Although the causal role of anxiety in suicidality remains unclear, anxiety disorders and suicidality could share genetic risk and common neurobiological mechanisms (dysregulation of inflammatory responses, alterations in the HPA-axis and the CRH, structural and functional abnormalities in brain regions related to reward and affect) or mutual risk factors (childhood maltreatment has been linked to both, anxiety disorders and suicidality) [47] (Figure 1). This evidence concerns the gene CRH and anxiety disorder.