Interestingly, induced pulmonary hypertension elicited a smaller increase in DNMT1 expression and activity in Mediterranean G6PD variant rats harboring a loss-of-function non-synonymous single nucleotide polymorphism (SNP; S188F; Type A-; G6PDS188F; severely deficient) than in their wild-type (WT) littermates [13]. Here, DNMT1 is linked to pulmonary arterial hypertension.