BAK1 and colonic neoplasm: Shun X. Ren et al. reported that antimicrobial peptide LL37, which exists in the human body, induces caspase-independent apoptosis by upregulating Bax and Bak and downregulating Bcl-2, leading to nuclear translocation of AIF and EndoG to induce caspase-independent apoptosis and thus inhibiting the occurrence of colon cancer [123].