In view of CP contribution in loading LF with iron [63] and the incapacity of iron-saturated LF to stabilize hypoxia-inducible factor 1-alpha while inducing ferroptosis in tumor cells [64], we suggest that Fe-LF/8OA will demonstrate more pronounced antitumor features, and we plan to test this hypothesis in future studies. This evidence concerns the gene HIF1A and neoplasm.