In recent years, new research has presented genetic markers implicated in the susceptibility to and severity of COVID-19 [24,54,55,56] and in the susceptibility and severity of hospitalized patients with syndrome Long COVID-19, but there was no association with different ACE-2 and transmembrane protease serine-2 (TMPRSS2) receptor polymorphisms [27]. This evidence concerns the gene ACE2 and COVID-19.