Despite showing a normal donor BMI, the UCP1- samples displayed an over-representation of transcripts associated with obesity (Figure 4b), including FGF9 (fibroblast growth factor 9), GRB7 (growth factor receptor-bound protein 7), COBL (cordon-bleu WH2 repeat protein), GPM6A (glycoprotein M6A), KLK7 (kallikrein 7), BMP3 (bone morphogenetic protein), and the human adipocyte-associated transcript FAM153A (encoding family with sequence similarity 153 member A). This evidence concerns the gene COBL and obesity due to melanocortin 4 receptor deficiency.