HMGB1 and breast carcinoma: This extract has been characterized by its cytotoxic properties in several cancer cell lines, induction of immunogenic apoptosis through the expression of extracellular calreticulin, high-mobility group box 1 (HMGB1) protein, and ATP, modulation of the immune response, and in vivo antitumor effect in murine models of breast cancer and melanoma [8].