HSD3B2 and polycystic ovary syndrome: When considering the steroidogenesis actors (Figure 1B), we showed that the steroidogenic acute regulatory protein (STAR) mRNA abundance was not significantly different in the two groups, while the mRNA levels of CYP11A1 (cholesterol chain cleavage enzyme, catalyzing the conversion of cholesterol to P5) and HSD3B2 (3β-hydroxysteroid dehydrogenase, catalyzing the biosynthesis of P4 from P5) were reduced by 56% (p = 0.008) and 38% (p = 0.034), respectively, in PCOS GCs as compared to controls.