Among all NLR members (22 up to now), NLRP3, NLRP1, NLRC4, and NLRP6 represent the most studied inflammasomes, involved in many inflammatory tissues pathologies, where NLRP3, NLRP1, and NLRC4 are mainly related to autoinflammatory skin disorders [4]. Here, NLRC4 is linked to skin disorder.