PON1 and Tinnitus: The cell-specific effects of ROS and the specificity of activators of TPAM1 may explain the relevance of data that correlate oxidative stress with the presence of tinnitus, as documented by the levels of total antioxidant status (TAS), thiols (antioxidant molecules that react with free radicals to prevent oxidative damage), and paraoxonase-1 (PON) activity (an enzyme preventing lipid peroxidation) [38,50,51].