The results of their study strongly suggest that deletion of the gene for renalase affects the composition of the microbiota and the abundance of certain bacteria in mice, and although it is pointed out that further studies are needed to describe the mechanisms in human models, it can be assumed that mouse models provide a good tool to study the pathogenesis and treatment of metabolic diseases, as they show genetic similarity to humans [34]. Here, RNLS is linked to metabolic disease.