RNLS and Hypertension: The study by Zhao et al., which was one of the first studies in humans on the effects of renalase on cardiovascular health, described that two (rs2576178 A > G and rs2296545 C > G) of the several studied single-nucleotide polymorphisms (SNP) of the RNLS gene (the gene responsible for encoding the renalase protein) were associated with the occurrence of hypertension in northern Han Chinese [47].