Although mutations causing early-onset FECD have been exclusively linked to the α2 chain of collagen VIII (COL8A2), which is a major component of Descemet’s membrane, the TCF4, TCF8, SLC4A11, ZEB1, LOXHD1 genes have been implicated in late-onset FECD [209,261]. This evidence concerns the gene LOXHD1 and Fuchs endothelial corneal dystrophy.