The significant canonical pathways based on the overlap percentage and p < 0.05 were coenzyme a biosynthesis, calcium transport I, TREM1 signaling, hepatic fibrosis signaling pathway, and estrogen receptor signaling, with overlap percentages of 66.7%, 40.0%, 13.9%, 7.6%, and 7.6%, respectively (Table 2A). The gene discussed is ESR1; the disease is Hepatic fibrosis.