The comparative study yielded common canonical pathways in both liver tissue and whole-blood-based studies, such as molecular mechanisms of cancer, NAFLD signaling pathway, hepatic fibrosis signaling, IL-6 signaling, and estrogen receptor signaling (Figure 6), indicating the utility of using blood samples for MASLD-associated transcription studies [15,16,17,18,19,20]. Here, ESR1 is linked to Hepatic fibrosis.