SREBF1 and cancer: For lipid anabolism, the mature form of lipogenic effector Sterol regulatory element-binding 1 (SREBP1) (Figure 5D) as well as cancer-favorable de novo biosynthesis for monounsaturated fatty acid (MUFA) were downregulated, whereas exogenous polyunsaturated fatty acid uptake was largely increased in response to PKM2 loss in SAS cells (Figure 5E).