PKM and oral cavity squamous cell carcinoma: The RNA data were further confirmed by immunohistochemistry and Western blot analysis showing that, in contrast to normal oral epithelium/Normal Human Oral Keratinocytes (NHOK), PKM2 protein expression was strongly detected in 4-nitroquinoline 1-oxide (4-NQO)-induced mouse hyperplastic tongue tissues and in human oral squamous cell carcinoma (Figure S2) as well as in human HNSC cells (Figure 2A).