On one hand, most studies pointed out that PKM2 is enriched in cancer cells and canonically regulates glycolysis to shape the tumorous metabolic characteristics [24]; on the other hand, a number of other studies showed that PKM2 exhibited a non-canonical function as a protein kinase or a nuclear transcriptional coactivator to regulate tumor malignancy [53,54,55]. Here, WEE1 is linked to cancer.