For lipid anabolism, the mature form of lipogenic effector Sterol regulatory element-binding 1 (SREBP1) (Figure 5D) as well as cancer-favorable de novo biosynthesis for monounsaturated fatty acid (MUFA) were downregulated, whereas exogenous polyunsaturated fatty acid uptake was largely increased in response to PKM2 loss in SAS cells (Figure 5E). Here, PKM is linked to cancer.