EZH2 and cancer: At the transcriptional level, the role of the dysregulation of DNMTs, TETs, and other related proteins like Polycomb protein EZH2 can be studied in order to analyze the importance of changes in DNA-methylation patterns in cancer establishment and progression and how the dynamic remodeling of DNA methylation is essential for the development and cell-fate decisions as cancer stem cells exit pluripotency during their differentiation [71].