APC, CDH13, and CDKN2A/P16 are more frequently hypermethylated in NSCLC, while genes related to apoptosis pathways (CASP8, TNFRSF6/Fas, and TRAIL-R1/DR4) are frequently methylated in SCLC cell lines and tumors [71]. The gene discussed is FAS; the disease is non-small cell lung carcinoma.