During the initial stage from normal tissue to polyps to cancer (polyp size ≤ 2 cm), matrix metalloproteinases MMP1, MMP3, and MMP7 increase steadily, playing a role in cancer proliferation, invasion, and metastasis through the remodeling of extracellular matrix, which is strongly associated with poor prognosis [11,12]. Here, MMP1 is linked to cancer.