The MSS group shows a high incidence of loss of HLA heterozygosity at chromosome 6 and 15 and coordinated transcriptional downregulation of the HLA-I heavy chain, β2-microglobulin, and antigen-presenting machinery genes, which correlate with fewer tumor-infiltrating lymphocytes, and the encapsulated phase, where the tumor is composed only of HLA-I negative cells with lymphocytes located in the stroma. Here, HLA-G is linked to neoplasm.