TP53 (78%), TTN (68%), CSMD3 (39%), MUT16 (36%), and RYR2 (36%) have the highest mutational frequency, and BRINP3, COL11A1, GRIN2B, MUC5B, NLRP3, and TENM3 have shown significantly higher mutational frequency in stage III of lung squamous cell carcinoma [32], while TP53, EGFR, KRAS, ALK, BRAF, MET, RET, and ROS1 are the most frequent mutation genes in lung adenocarcinoma [33]. This evidence concerns the gene TP53 and lung adenocarcinoma.