Different types of myosin have been found to be involved in herpesvirus infection, mediating the entry of the Epstein–Barr virus, participating in capsid assembly, transportation, and release of Kaposi’s sarcoma-associated herpesvirus, facilitating the entry of the Singapore grouper iridovirus into fish cells and the internalization of feline infectious peritonitis virus, and being necessary for efficient production, nuclear egress, and capsid localization during human cytomegalovirus infection. Here, MYH14 is linked to Herpesviridae infectious disease.