Along with executing the biological responses for cell survival and proliferation, FAK activation acts as a mediator of several events fine-tuning metastatic progression of cancer cells, including rearrangements of the cytoskeleton, promotion of epithelial to mesenchymal (EMT) traits, upregulation of MMPs to facilitate invasion, and extracellular matrix remodeling [36]. The gene discussed is PTK2; the disease is cancer.