EZH2 and neoplasm: An analysis of 5970 TCGA tumor samples revealed that the association between lncRNAs and the DNA methylation mechanisms was common and conserved across multiple cancer types, e.g., a complex interplay between lncRNAs and epigenetic modulators, such as DNA cytosine methyltransferases DNMT1, and histone modification proteins, such as EZH2 (Figure 4).