Although the exact mechanisms that contribute to the escape from TRAIL-induced apoptosis and the progress of resistance to TRAIL in tumor cells have not yet been fully unraveled, downregulating pro-apoptotic proteins and DR4/5, concomitant with modulating intracellular pro- and anti-apoptotic proteins, would seem to be of paramount importance [19]. The gene discussed is TNFRSF10A; the disease is neoplasm.