Quercetin was able to sensitize TRAIL-resistant pancreatic cancer (8988 T) and breast cancer cell lines (BT-20 and MCF-7 cells) to TRAIL-induced apoptosis These effects were associated with the reduced expression of the c-FLIP protein, resulting from JNK-mediated protein degradation, as well as the transcriptional upregulation of DR5, respectively [62,64]. This evidence concerns the gene TNFSF10 and familial pancreatic carcinoma.