It is noteworthy that the TRAIL-sensitizing effects observed in a variety of cancer cell lines after combinatory treatment with different flavonoids (i.e., apigenin, luteolin, chrysin, linarin, galangin, quercetin, kaempferol, casticin, amurensin G, genistein, irigenin, epigallocatechin-3-gallate, icaritin, kurarinone, and icariside II) were associated with the decreased expression of c-FLIP (Table 1; Figure 3). The gene discussed is CFLAR; the disease is cancer.