Finally, galangin (3,5,7-trihydroxyflavone), abundant in propolis and in the rhizome of Alpinia officinarum, potentiated TRAIL-mediated apoptosis in TRAIL-resistant renal carcinoma Caki cells and in human breast cancer cell lines (MCF-7 and T47D) by affecting the expression of Bcl-2, c-FLIP, Mcl-1, and survivin at post-translational levels, and the AMPK signaling pathway, respectively [59,60]. Here, CFLAR is linked to breast cancer.