More recently, the combination of isoquercitrin, an active metabolite isolated from the leaves of the mangrove tree Avicennia marina, and/or rhTRAIL was shown to markedly increase DR4 and DR5 expression in the cervical cancer cell line SiHa, although the increase in the percentage of apoptosis was exiguous, probably due to the presence of other anti-apoptotic proteins [70]. The gene discussed is TNFRSF10B; the disease is cervical cancer.