Genistein, a major isoflavone compound in soybeans and soy products, has been reported to enhance TRAIL-induced apoptosis in the endometrial cell line Ishikawa and in TRAIL-resistant A549 human lung adenocarcinoma cells by unleashing the death receptor signaling pathway (increase in DR4 and DR5, reduction in c-FLIP) and by inhibiting autophagic flux, respectively [71,72]. Here, TNFSF10 is linked to lung adenocarcinoma.