Non-toxic concentrations of linarin (a glycosylated flavone identified from various plant species mainly belonging to the Asteraceae and Lamiaceae families) and liquiritin (a major constituent of Glycyrrhiza Radix) significantly potentiated the TRAIL-driven cell death of human malignant glioma cells (U87MG) and gastric adenocarcinoma cell lines (AGS and SNU-216, IC50: 79.56 and 78.69 μM respectively), in vitro and in vivo, through ROS generation and the activation of intrinsic and extrinsic apoptotic pathways [56,57]. The gene discussed is TNFSF10; the disease is gastric adenocarcinoma.