TNFSF10 and hepatocellular carcinoma: The authors also reported that chrysin improved TRAIL-mediated apoptosis in other human cancer cell lines, including breast cancer (MDA-MB-231), CRC (HT-29), HCC (HepG2), melanoma (SK-MEL-37), and pancreatic carcinoma (Capan-1) cell lines, by the same mechanism [53].