Combined treatment with auriculasin, a prenylated isoflavone found in various food ingredients, such as the roots of Flemingia philippinensis, the stem bark of Erythrina senegalensis, and osage orange fruits, and TRAIL resulted in tumor-specific apoptotic cell death in RC-58T/h/SA#4 primary prostate cancer cells, characterized by DNA fragmentation, the accumulation of apoptotic cell populations, and nuclear condensation. Here, TNFSF10 is linked to prostate carcinoma.