Finally, Nazim et al. reported that cotreatment with luteolin and TRAIL markedly initiated the death of Huh7 and Hep3B HCC cells, which are highly resistant to treatment with luteolin or TRAIL alone, through a mechanism that involved the induction of autophagy and JNK-mediated expression of DR5 [48]. The gene discussed is TNFSF10; the disease is hepatocellular carcinoma.