Subtoxic concentrations of chrysin selectively enhanced TRAIL-induced apoptosis in HCC cells (Hep3B, Huh-7, and Hep G2) but not in human embryo liver L-02 cells or normal human peripheral blood mononuclear cells (PBMCs), by endoplasmic reticulum (ER) stress-dependent CCAAT enhancer-binding protein homologous protein (CHOP)-mediated DR5 upregulation [51]. The gene discussed is TNFSF10; the disease is hepatocellular carcinoma.