TNFSF10 and colorectal carcinoma: In detail, casticin, a flavonoid isolated from Vitex rotundifolia and widely used as an anti-inflammatory agent in Chinese traditional medicine, was found to enhance the TRAIL-induced apoptosis of CRC cells (HT-29, HCT-116, SW480) through the downregulation of cell survival proteins (Bcl-xL, Bcl-2, survivin, XIAP, and c-FLIP) and the ROS-mediated induction of DR5 [68].