Finally, Kim et al. reported that icariin, a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum, increased the effects of TRAIL to induce apoptosis in the CRC cell line HCT-116 in vitro and to reduce the in vivo growth of HCT-116-derived tumors in a xenograft mouse model via the ROS-, ERK-, and CHOP-mediated upregulation of DR5 and DR4 [90]. The gene discussed is TNFRSF10B; the disease is colorectal carcinoma.