DDIT3 and ovarian cancer: Yi et al. showed that quercetin enhanced the apoptotic death of ovarian cancer cells (SKOV-3, OVCAR-3, and TOV-21G) to TRAIL (IC50 values for quercetin: SKOV-3: 153.3 ± 4.03 μM, OVCAR-3: 147.4 ± 3.86 μM, and TOV-21G: 159.4 ± 3.64 μM) via the upregulation of the CHOP-induced expression of DR5 after ROS-mediated endoplasmic reticulum stress.