Regarding the flavanol family, epigallocatechin-3-gallate (EGCG), a major constituent of green tea with anti-diabetes, anti-obesity, anti-inflammatory, and antitumor effects, sensitized human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis by the downregulation of c-FLIP, Mcl-1, and Bcl-2 [78]. This evidence concerns the gene TNFSF10 and hereditary clear cell renal cell carcinoma.