TNFSF10 and malignant colon neoplasm: Kauntz et al. investigated the effect of silibinin, a flavonolignan that is the main active component of the milk thistle plant (Silybum marianum), and TRAIL in an in vitro model of human colon cancer progression, consisting of primary colon tumor cells (SW480) and their derived TRAIL-resistant metastatic cells (SW620).