TNFSF10 and neuroblastoma: Finally, prenylated chalcone xanthohumol in combination with TRAIL was shown to significantly increase DR5 expression and the percentage of apoptosis in human cervical cancer (HeLa) and neuroblastoma (NGP, SH-SY-5Y, and SK-N-AS) cell lines compared to TRAIL or xanthohumol alone [76,83].