AGT and polycystic ovary syndrome: Interestingly, contractility was also increased in our vitamin D-deficient PCOS female rats, which may be due to androgens enhancing the vascular response to angiotensin II [30,31]; the Ang II-induced vasoconstriction in endothelium-intact and endothelium-denuded uterine arteries of pregnant Sprague–Dawley rats was enhanced by elevated testosterone levels [29].