Indeed, we previously demonstrated that FLNA is able to bind IGF1R, and FLNA silencing induced a reduction in the IGF1R expression and a simultaneous decrease in ERK phosphorylation, cyclin E1 expression, and cell proliferation in human ACC cell line H295R and in primary cultured ACC cells [19], supporting a role for FLNA as a suppressor of IGF2 signalling. Here, FLNA is linked to adrenal cortex carcinoma.