DYRK2 and neoplasm: According to the reviewed data [66], a clear association between DYRK2 expression and mutations and the poor prognosis in cancer patients was established; for example, the process of phosphorylation and methylation of DYRK2 was different in normal and tumor tissues but also in the tumor microenvironment, while the expression of DYRK2 in cells was correlated with the cancer-associated fibroblast infiltration process.