CASP1 and atrial fibrillation: The activation of the NLRP3 inflammasome also plays a pathogenetic role in atrial fibrillation: in affected patients, IL-1, IL-18, and TNF-α levels positively correlate with the progression of disease [40,41]; while NLRP3, ASC, and pro-caspase 1 levels remain unchanged, caspase 1-p20 protein levels are increased.