To demonstrate the direct involvement and prominent role of inflammatory signaling in atrial fibrillation promotion, Yao et al. set up a model of cardiomyocyte-specific knock-in mice that developed spontaneous premature atrial contractions and inducible atrial fibrillation, attenuated by the administration of a specific NLRP3-inflammasome inhibitor [42]. Here, NLRP3 is linked to atrial fibrillation.