NLRP3 and atrial fibrillation: Marín-Aguilar et al. showed that ablation of the NLRP3 inflammasome in mice reduced telomere shortening and rescued from the setting of age-related insulin resistance, with a reduction of leptin/adiponectin ratio, IGF-1 levels, and decreased cardiac damage; also the prolongation of PR interval in ECG, marker of age-associated atrial fibrillation, was prevent [63].