IL6 and myocardial infarction: The monocyte chemotactic protein 1 (MCP-1) is increased in post-myocardial infarction areas [33]; this chemoattractant gradient for monocytes/macrophages could be sustained through a circuit involving IL-6 that, secreted by damaged cells, binds the soluble circulating receptor IL-6R forming a complex that trigger signals through the membrane gp130, making injured cells responsive to IL-6 (transsignaling of IL-6), and inducing them to produce MCP-1 [34].