Accordingly, many evidences strengthen the pathogenetic role of inflammasome and that its blockade rescue from atherosclerosis: increased levels of mRNA for NLRP3, ASC, caspase-1, IL-1β, and IL-18 in plaques [55]; high levels of IL-1β and IL-1 receptor 1 (IL-1R1) within atherosclerotic arteries [56]; on the other side, raised levels of IL-1Ra so as lack of expression of IL-18 in association with reduction of atherosclerosis in coronaries and in a murine model of atherosclerosis respectively [56,57,58]. Here, PYCARD is linked to atherosclerosis.