NLRP3 activation is also involved in initiating and promoting the development of nonalcoholic steatohepatitis (NASH) [73]; in vivo and in vitro experimental studies demonstrated that activation of the NLRP3 inflammasome is mainly associated with NASH, but not with steatosis [74] (Figure 5). Here, NLRP3 is linked to metabolic dysfunction-associated steatohepatitis.