A previous study demonstrated that CXCL14 could activate the p38/JNK signaling pathway, and up-regulate the expression of StAR, which is a key enzyme in progesterone synthesis, and promote progesterone synthesis through cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation in a polycystic ovary syndrome (PCOS) human model [30]. The gene discussed is CREB1; the disease is polycystic ovary syndrome.