Furthermore, it has been demonstrated that long-term intake of FaOH and FaDOH downregulates the gene expression of cyclooxygenase-2 (COX-2) as well as the inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor α (TNFα) in the colonic epithelium in a rat model of colorectal cancer (CRC) [4]. This evidence concerns the gene PTGS2 and colorectal carcinoma.