PTGS2 and cancer: A connection between CRC and COX-2 overexpression has been established in accordance with the chemopreventive effect of FaOH and FaDOH in a rat model for CRC [24,25], and just recently, we demonstrated that intake of carrot juice in healthy human individuals reduced the secretion of inflammatory cytokines like IL-1α and IL-16, not of COX-2, IL-6, and TNFα, following LPS stimulation ex vivo, which are all known players in cancer development [1].