Synaptic loss is a common hallmark of dementia, involving both specific presynaptic as well as postsynaptic proteins, which are postsynaptic density protein (PSD-95), synaptosomal-associated protein 23 (SNAP-23), synaptosomal-associated protein 25 (SNAP-25), and synaptophysin (SYP). Here, DLG4 is linked to dementia.