INS and Hyperglycemia: For outpatients with hyperglycaemia receiving EN, drug treatment can follow the same recommendations and clinical practice guidelines as any other patient with hyperglycaemia (for both insulin and other non-insulin antidiabetic agents) [3], although it is true that there is very little literature on the administration of oral antidiabetic drugs using a feeding tube, and the safety of crushing and administering antidiabetic drugs through a feeding tube is not always known.