Moreover, a study by Ito et al. demonstrated that Cdc42 mediates p53-induced vascular inflammation in vivo, increases the expression of proinflammatory molecules in endothelial cells by activating the NF-κB pathway, and plays a crucial role in endothelial Cdc42 in chronic inflammation and the development of atherosclerosis [219]. The gene discussed is CDC42; the disease is inflammation.