IL6 and ischemia: The mechanisms underlying this phenomenon are diverse, including poor dietary choices, increased iron requirements, elevated iron loss, inflammation, foot strike hemolysis, thermochemolytic sweat loss, exercise-induced ischemia leading to gastrointestinal iron loss, hematuria, and decreased iron absorption due to exercise-induced surges in hepcidin mediated by interleukin 6 (IL-6) [5,7,17].