Probiotic consumption significantly changed FPG by −15.92 mg/dL and HbA1cby −0.54% compared with control groups. Subgroup analysis was conducted in to trials with non-yogurts control. Meta-analysis of trials with multiple species of probiotics found a significant reduction in FPG. The duration of intervention for ≥8 weeks resulted in a significant reduction in FPG. The results also showed that probiotic therapy significantly decreased homeostasis model assessment of insulin resistance (HOMA-IR) and insulin concentration. Here, INS is linked to Insulin resistance.