In a study with available data on omega-3 and incident dementia in 102,722 participants, both plasma DHA and total omega-3 (expressed as proportion of total fatty acids) related to a significantly lower risk of incident dementia in a model including age, sex, education, and APOLIPOPROTEIN-E (APOE)-ɛ4 status as covariates, although the statistical significance was blunted after the inclusion of sociodemographic, cardiovascular and lifestyle variables in the models [13]. The gene discussed is APOE; the disease is dementia.