Prominent among the elevated obesity-associated circulating adipokines and cytokines are the C-reactive protein (CRP) [5,6], Semaphorin-3C (Sema3C), Tumor Necrosis Factor-alpha (TNF alpha), Interleukin-6 (IL-6) [7], Monocyte Chemoattractant Protein-1 (MCP1) [7], and Interleukin-8 (IL-8) [8]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.