In one case report, a novel homozygous missense variant of c.524G > T in FOLR1 was identified in a CFD patient, but the authors did not investigate the FRAb status further [44]; however, according to the whole exome sequencing conducted by Ramaekers et al., no specific mutations of FOLR1 and FOLR2 in the coding region were found to be correlated with CFD [45]. Here, FOLR2 is linked to fleck corneal dystrophy.