Interestingly, most participants (5 out of 6 subjects enrolled) who presented missense variants of KDM6B were also FRAb-positive in their serum samples [46]; moreover, considering the role of KDM6B in regulating T-cell differentiation and anti-tumor or autoimmune response [47,48,49], it is possible that KDM6B mutations may be involved in the pathological production of autoantibodies against FRα. This evidence concerns the gene KDM6B and neoplasm.