When HINT1 is overexpressed in SW480 and McF-7 tumor cells, it leads to a decrease in Bcl-2 levels, an increase in Bax levels, and elevated expression of caspase-9, caspase-8, and caspase-3, ultimately resulting in the induction of apoptosis in tumor cells [12]. The gene discussed is CASP8; the disease is neoplasm.