In HCC, hypoxia-induced HIF activation promotes the secretion of pro-angiogenic factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and angiopoietin-2 (Ang-2), which stimulate the formation of new blood vessels and the recruitment of endothelial cells [22]. The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.