The examination of larger families with an autosomal-dominant MVP trait resulted in the identification of three loci for genetic myxomatous MVP, with MMVP 1 being located on chromosomes 16p11.2–p12.1 [35], MMVP2 on chromosome 11p15.4 [36], and MMVP 3 on chromosomes 13q31.3–q32.1 [37]. The gene discussed is DCHS1; the disease is familial mitral valve prolapse.