In a patient with bileaflet MVP and frequent multifocal PVCs and the affected maternal aunt, whole-exome sequencing identified a novel truncating variant in FLNC-encoded Filamin C (p.Trp34*-FLNC) as a potential proarrhythmic genetic substrate for arrhythmogenic bileaflet MVP syndrome [77]. The gene discussed is FLNC; the disease is familial mitral valve prolapse.