Notably, in vitro studies investigating two FlnA–G288R and P637Q mutations in human melanoma and fibrosarcoma cell lines delineated an altered balance of the small GTPases RhoA and Rac1 involved in the actin cytoskeleton during cell adhesion, with spreading and migration providing a potential mechanism contributing to the pathogenesis of MVP [33]. Here, FLNA is linked to familial mitral valve prolapse.