Our patient initially was considered as an obligate carrier for haemophilia A (father with a moderate form of the disease), and was diagnosed with severe form of haemophilia A, due to her FVIII level (˂1%), her biomolecular finding (missense mutation on exon 14, codon 391), and an associated chromosomal abnormality (46,X,i(Xq). Here, F8 is linked to hemophilia A.