Heterozygous mutations in p63 give rise to a plethora of rare syndromes that are very similar to each other [11]: Ectrodactyly-Ectodermal dysplasia Clefting (EEC) syndrome, Rapp Hodgkin (RHS) syndrome, Hay Wells or Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) syndrome, limb-mammary (LMS) syndrome, AcroDermato-Ungual-Lacrimal-Tooth (ADULT) syndrome, and Split-Hand/Foot Malformation type 4 (SHFM4) syndrome. This evidence concerns the gene TP63 and EEC syndrome.