Moreover, NP tissues showed an upregulation of PAFR mRNA expression as well as Lyso-PAF isoforms compared to healthy NM tissues, suggesting that the PAF/PAFR system could play a pathophysiological role in the pathogenesis of CRSwNP, opening the possibility of developing anti-PAF drugs to treat patients with CRSwNP. This evidence concerns the gene PTAFR and chronic rhinosinusitis with nasal polyps.