PCLAF and chronic rhinosinusitis with nasal polyps: Moreover, NP tissues showed an upregulation of PAFR mRNA expression as well as Lyso-PAF isoforms compared to healthy NM tissues, suggesting that the PAF/PAFR system could play a pathophysiological role in the pathogenesis of CRSwNP, opening the possibility of developing anti-PAF drugs to treat patients with CRSwNP.