In our cohort, autoantibody positivity was reported in all patients, with only one case reporting no clinical evidence of related autoimmune disorders and with four patients presenting more than one type (positivity for anti-glutamic acid decarboxylase, anti-islet cell, anti-insulin, anti-thyroid peroxidase, anti-nuclear, anti-transglutaminase, anti-parietal cell, and anti-adrenal antibodies, as well as rheumatoid factor, was observed). The gene discussed is TPO; the disease is autoimmune disease.