PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In addition, specific ethnicities overrepresented in prisons compared to the general population (i.e., Hispanics) have been associated with increased genetic susceptibility to MASLD, frequently attributed to single nucleotide polymorphisms (SNPs) in well-established genes, including PNPLA3 (patatin-like phospholipase domain containing 3) and TM6SF2 (transmembrane 6 superfamily member 2) [24].